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Association details:
| Biomarker: | BRCA2 overexpression |
|---|---|
| Cancer: | Estrogen Receptor Positive Breast Cancer |
| Drug: | Lynparza (olaparib) (PARP inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
High BRCA2 Gene Expression is Associated with Aggressive and Highly Proliferative Breast Cancer
Published date:
05/08/2021
Excerpt:
BRCA2 high expression significantly correlated with response to olaparib, a PARP inhibitor...BRCA2 high gene expression was associated with highly proliferative and aggressive breast cancer that was highly immunogenic with better response to PARP inhibitors in ER-positive patients.
DOI:
10.1245/s10434-021-10063-5
