^
Association details:
| Biomarker: | BRCA2 mutation |
|---|---|
| Cancer: | Solid Tumor |
| Drug: | ART558 (DNA polymerase theta inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Pol? inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
Published date:
06/17/2021
Excerpt:
In addition, ART558 elicits DNA damage and synthetic lethality in BRCA1- or BRCA2-mutant tumour cells...
DOI:
10.1038/s41467-021-23463-8
