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Association details:
| Biomarker: | BRCA2 A902fs*2 |
|---|---|
| Cancer: | Prostate Cancer |
| Drug: | cisplatin (DNA synthesis inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Effect of cisplatin on metastatic castration-resistant prostate cancer with BRCA2 mutation: A case report
Published date:
05/17/2021
Excerpt:
A 37-year old man with Pca...After the disease progressed while the patient underwent taxane-based chemotherapy, we performed a genetic test by FoundationONE CDx...Genetic testing revealed a frameshift mutation with a stop codon two positions further in the BRCA2 (pA902fs*2)...Thus, we administered cisplatin, the only platinum drug approved to treat PCa...Thereafter, the PSA continued to decrease...This case suggests potential predictive role of BRCA2 mutation for cisplatin in patients with mCRPC.
DOI:
10.1016/j.eucr.2021.101712
Test:
