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Association details:
| Biomarker: | BRCA1 S451Lfs*20 |
|---|---|
| Cancer: | Gallbladder Cancer |
| Drug: | Lynparza (olaparib) (PARP inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Olaparib Treatment in a Patient with Advanced Gallbladder Cancer Harboring BRCA1 Mutation
Published date:
04/21/2021
Excerpt:
...73-year-old Asian patient diagnosed with lymph nodes and peritoneal metastases just two months after surgery for primary gallbladder cancer....NGS result of germline BRCA1 mutation, the patient was administered first-line Olaparib and obtained a progression-free survival of about 6 months....first report of germline BRCA1 p. S451Lfs*20 mutation and first-line Olaparib usage in a metastatic gallbladder cancer patient.
DOI:
https://doi.org/10.2147/OTT.S303594
