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Association details:
| Biomarker: | BRCA1 Q858 |
|---|---|
| Cancer: | Gallbladder Cancer |
| Drug: | Lynparza (olaparib) (PARP inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Response of BRCA1-mutated gallbladder cancer to olaparib: A case report
Published date:
12/14/2016
Excerpt:
A 74-year-old man...revealed multiple low-density intrahepatic lesions as well as the gallbladder lesion...we also detected a germinal BRCA1 Q858* mutation...the patient was started on olaparib 400 mg twice daily...The patient responded well to olaparib until the occurrence of obstructive jaundice.
DOI:
10.3748/wjg.v22.i46.10254
