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Association details:
| Biomarker: | BRCA1 mutation + RAD51B deletion |
|---|---|
| Cancer: | Triple Negative Breast Cancer |
| Drug: | carboplatin (Tubulin polymerization promoter) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Major Response to Carboplatin in a Patient With Metastatic Triple-Negative Breast Cancer With Somatic Mutation of BRCA1 and Loss of RAD51B
Excerpt:
Here, we present a case of an almost complete response to carboplatin in a heavily pretreated metastatic TNBC with somatic BRCA1 mutation and RAD51B deletion.
DOI:
10.1200/PO.18.00362
