^
Association details:
| Biomarker: | BRCA1 L1780P |
|---|---|
| Cancer: | Estrogen Receptor Positive Breast Cancer |
| Drug: | carboplatin (Tubulin polymerization promoter) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Molecular Characterization of BRCA1 c.5339T>C Missense Mutation in DNA Damage Response of Triple-Negative Breast Cancer
Published date:
05/13/2022
Excerpt:
BRCA1 L1780P mutant TNBC cells showed increased migration and invasion capacity, as well as increased sensitivity to olaparib and carboplatin compared to BRCA1 wild-type cells. BRCA1 L1780P mutant TNBC cells showed decreased RAD51 expression and reduced nuclear RAD51 foci formation following carboplatin and olaparib treatment.
DOI:
10.3390/cancers14102405
