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Association details:
Biomarker:BRCA1 expression
Cancer:Germ Cell Tumors
Drug:Lynparza (olaparib) (PARP inhibitor)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: D – Preclinical
Source:
Title:

Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors

Published date:
01/01/2021
Excerpt:
...we demonstrated the sensitivity of TGCT cell lines to Olaparib, which associated with differential methylation levels of a subset of targets, namely BRCA1 and RAD51C...the cell line least responsive to Olaparib (TCam-2) presented the highest BRCA1 and RAD51C expression levels.
DOI:
10.1002/1878-0261.12909