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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

EGFR signaling promotes resistance to CHK1 inhibitor prexasertib in triple negative breast cancer

Published date:
12/05/2020
Excerpt:
We first examined the sensitivity of a panel of TNBC cell lines to prexasertib...Prexasertib effectively induced cell death at nanomolar concentrations for most TNBC cell lines, including BRCA mutated HCC1937 and MX-1...The highest sensitivity to prexasertib was observed in MX-1 cells (orange line, IC50, 5.7 nmol/L), while MDA-468 cells were highly resistant (blue line, IC50, 105 nmol/L).
DOI:
10.20517/cdr.2020.73