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Association details:
| Biomarker: | BRAF V600R |
|---|---|
| Cancer: | Melanoma |
| Drug: | Mekinist (trametinib) (MEK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Phase II Study of the MEK1/MEK2 Inhibitor Trametinib in Patients With Metastatic BRAF-Mutant Cutaneous Melanoma Previously Treated With or Without a BRAF Inhibitor
Excerpt:
One patient each with BRAF K601E and BRAF V600R had prolonged PR.
DOI:
10.1200/JCO.2012.43.5966
Trial ID:
