^
Association details:
Biomarker:BRAF V600E
Cancer:Melanoma
Drug:U0126 (MEK1 inhibitor, MEK2 inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Source:
Title:

CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations

Excerpt:
D594G (WM3629) and the G469E (WM3670) melanoma cell lines are nearly completely resistant to the growth inhibitory effects of the MEK inhibitor U0126, In contrast, the melanoma cell lines harboring either the BRAF V600E or K601E mutation were markedly growth inhibited following U0126 treatment.
DOI:
10.1038/onc.2008.362