^
Association details:
| Biomarker: | BRAF V600E |
|---|---|
| Cancer: | Melanoma |
| Drug: | SB-590885 (BRAF inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K
Excerpt:
Chronic treatment of additional BRAFV600E melanoma cell lines with 885 led to the emergence of drug resistance.
DOI:
https://doi.org/10.1016/j.ccr.2010.11.023
