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Association details:
| Biomarker: | BRAF V600E |
|---|---|
| Cancer: | Melanoma |
| Drug: | mirdametinib (PD-0325901) (MEK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
BRAF mutation predicts sensitivity to MEK inhibition
Excerpt:
Daily treatment with PD0325901 at doses of 5 and 25 mg kg−1 completely suppressed the growth of SKMEL28 and Colo205 BRAF(V600E) mutant xenografts (Fig. 4a and Supplementary Fig. S3; P < 0.01 for both 5 and 25 mg kg−1 versus control, P = 0.16 for 5 versus 25 mg kg−1).
DOI:
10.1038/nature04304
