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Association details:
| Biomarker: | BRAF V600E |
|---|---|
| Cancer: | Melanoma |
| Drug: | CB-006-3 (PI3K inhibitor, BRAF V600E inhibitor, PI3Kδ inhibitor, PI3Kγ inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Computational high-throughput screening and in vitro approaches identify CB-006-3; A novel PI3K-BRAFV600E dual targeted inhibitor against melanoma
Published date:
10/10/2022
Excerpt:
Further, the compound dose dependently inhabited BRAFV600E enzyme with an IC50 value of 70.84 nM (Fig. 6c). In order to evaluate if the enzyme inhibitory effects of CB-006-3 is translated into the anticancer efficacy, we carried out the antiproliferative assay with the compound in A375 and G-361 melanoma cells. As observed in Fig. 6d, the compound inhibited the proliferation of both these cells with respective GI50 values of 223.3 and 143.6 nM.
DOI:
10.32604/or.2022.025187
