^
Association details:
| Biomarker: | BRAF V600E |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | Lonsurf (trifluridine/tipiracil) (Thymidine phosphorylase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
107P - Safety and efficacy of trifluridine/tipiracil (FTD/TPI) in previously treated metastatic colorectal cancer (mCRC): Results from the Australian cohort of the phase IIIb, international, open-label, early-access PRECONNECT study
Published date:
11/17/2020
Excerpt:
60% had...10% had BRAF-(V600E) mutant cancers...FTD/TPI was associated with a median PFS of 2.7 months (95% CI, 2.4–3.4) and disease control rate of 40% (95% CI, 28.47–52.41)….Results from the Australian cohort are consistent with the global PRECONNECT population and randomised datasets in previously treated mCRC patients.
Trial ID:
Source:
Title:
A Phase 3 Multicenter, Randomized, Open-label, Active-controlled Study of Sotorasib and Panitumumab Versus Investigator's Choice (Trifluridine and Tipiracil, or Regorafenib) for the Treatment of Previously Treated Metastatic Colorectal Cancer Subjects with KRAS p.G12C Mutation Μια Πολυκεντρική, Τυχαιοποιημένη, Ανοιχτού Σχεδιασμού, Ελεγχόμενη με Δραστικό Φάρμακο Δοκιμή Φάσης 3 του Συνδυασμού Σοτορασίμπης και Πανιτουμουμάμπης Έναντι της Θεραπείας Επιλογής του Ερευνητή (Τριφλουριδίνη και Τιπιρακίλη, ή Ρεγοραφενίμπη) για την Αντιμετώπιση Ασθενών που Φέρουν τη Μετάλλαξη KRAS p.G12C και Είχαν Λάβει Προηγούμενη Θεραπεία για Μεταστατικό Ορθοκολικό Καρκίνο
Excerpt:
...Notes: Subjects with tumors known to be MSI-H must have received prior checkpoint inhibitor therapy if available in the region unless there is a medical contraindication, in which case, the subject may be eligible after investigator discussion with Amgen medical monitor.Subjects with tumors known to have BRAF V600E mutation must have received prior treatment with encorafenib and cetuximab if available for this indication in the country or region.Adjuvant therapy will count as a line of therapy for metastatic disease if the subject progressed on or within six months of completion of adjuvant therapy administration. ...
Trial ID:
