^
Association details:
| Biomarker: | BRAF V600E |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | mirdametinib (PD-0325901) (MEK inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes
Excerpt:
As such, we found that overexpression of BRAFV600E in HT29 cells made them unresponsive to treatment with PD-0325901, while they remained entirely sensitive to DEL-22379.
DOI:
https://doi.org/10.1016/j.ccell.2015.07.001
