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Association details:
| Biomarker: | BRAF V600E + PTEN deletion |
|---|---|
| Cancer: | Melanoma |
| Drug: | HI-511 (BRAF inhibitor, Aurora kinase B inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
HI-511 overcomes melanoma drug resistance via targeting AURKB and BRAF V600E
Published date:
08/01/2020
Excerpt:
The BRAF V600E mutant/PTEN-loss mouse experiment was conducted to determine the effect of HI-511 on melanoma development in mice. Treatment with HI-511 (10, 50 mg/kg B.W.) strongly inhibited tumor growth in a dose-dependent manner compared with the vehicle control-treated group...
DOI:
10.7150/thno.44342
