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Association details:
| Biomarker: | BRAF V600DK601del |
|---|---|
| Cancer: | Melanoma |
| Drug: | Zelboraf (vemurafenib) (BRAF inhibitor, BRAF V600E inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The clinical response to vemurafenib in a patient with a rare BRAFV600DK601del mutation-positive melanoma
Excerpt:
In February 2007, a 66 year-old woman was diagnosed as having a 2.35 mm cutaneous nodular thoracic melanoma and underwent complete excision with 2 cm margins....We used the BRAF inhibitor vemurafenib to treat a patient presenting a rare p.V600_K601delinsD-mutated melanoma. An objective response was evidenced by two months of progression-free survival.
DOI:
10.1186/1471-2407-14-727
