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Association details:
| Biomarker: | BRAF mutation |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | ERAS-601 (PTPN11 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
2671/14 - ERAS-601, a potent allosteric inhibitor of SHP2, demonstrates anti-tumor activity in RAS/MAPK-driven tumor models
Published date:
03/09/2022
Excerpt:
...in the NCI-H358 xenograft model. ERAS-601 also inhibits tumor growth in multiple RAS/MAPK-driven CDX and PDX models that harbor EGFR, KRAS, BRAF Class III, and NF1LOF mutations. ERAS-601 is a potent and selective allosteric SHP2 inhibitor that demonstrates anti-tumor activity in vitro and in vivo...
