Pts with mutations associated with poor prognosis in CLL had significantly better PFS with zanu than with BR (eg, ATM [P=.02], BRAF [P=.01], NOTCH1 [P<.001], SF3B1 [P<.001]; Table)….TN del(17p)-negative pts with CLL/SLL were evenly distributed between zanu and BR arms in SEQUOIA cohort 1 based on the biomarkers analyzed.