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Association details:
| Biomarker: | BRAF mutation + TERT overexpression |
|---|---|
| Cancer: | Melanoma |
| Drug: | Cotellic (cobimetinib) (MEK1 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
TERT Expression Induces Resistance to BRAF and MEK Inhibitors in BRAF-Mutated Melanoma In Vitro
Published date:
05/24/2023
Excerpt:
A375RES and SkMel28RES showed, respectively, a 20- to 32-fold increased resistance to vemurafenib and a 45- to 55-fold increased resistance to cobimetinib in comparison to parental cell lines....The mRNA of expression of TERT was increased significantly in A375RES and SkMel28RES as compared to parental cells.
DOI:
10.3390/cancers15112888
