^
Association details:
Biomarker:BRAF mutation + MSI-L/dMMR
Cancer:Lung Adenocarcinoma
Drug Class:Immunotherapy
Direction:Resistant
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
Source:
Title:

2226 / 8 - Precise stratification of immunotherapy outcomes using response-associated somatic mutations

Published date:
05/27/2020
Excerpt:
All patients had received at least one dose of an ICI (anti-PD-1/PD-L1, anti-CTLA-4 or both)...we identified 14 ICI-response associated genes (IRAGs) across 6 cancer types. We verified that these IRAGs were predictive rather than prognostic...while 11 IRAGs were associated with worse outcomes in MSI-L tumors....Our results suggest that these IRAGs could be used in combination with MSI and/or TMB status to more precisely predict ICI treatment outcomes.