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    Association details:
    Biomarker:BRAF L597R
    Cancer:Non Small Cell Lung Cancer
    Drug:Mekinist (trametinib) (MEK inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C4 – Case Studies
    Source:
    J Thorac Oncol
    Title:

    Molecular Landscape of BRAF-Mutant NSCLC Reveals an Association Between Clonality and Driver Mutations and Identifies Targetable Non-V600 Driver Mutations

    Published date:
    06/12/2020
    Excerpt:
    Three patients were treated with MEK +/- BRAF inhibitors. Patients harboring G469V and D594G mutations did not respond, while a patient with L597R mutation had durable response.
    DOI:
    10.1016/j.jtho.2020.05.021