^
Association details:
| Biomarker: | BRAF G469E |
|---|---|
| Cancer: | Melanoma |
| Drug: | sorafenib (Multi-tyrosine kinase inhibitor, pan-RAF inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations
Excerpt:
Interestingly, the D594G mutated melanoma line WM3629 was highly sensitive to growth inhibition following treatment with sorafenib, whereas the cell lines with the V600E, G469E and K601E BRAF mutations were growth inhibited, but not as highly sensitive.
DOI:
10.1038/onc.2008.362
