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Association details:
| Biomarker: | BRAF G469E |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | Mekinist (trametinib) (MEK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Trametinib Activity in Patients with Solid Tumors and Lymphomas Harboring BRAF Non-V600 Mutations or Fusions: Results from NCI-MATCH (EAY131)
Excerpt:
Among 50 patients assigned, 32 were eligible and received therapy with trametinib...se (with 50% tumor shrinkage) but died suddenly at 4.3 months (potentially drug-related, and of unknown cause) without progression.
DOI:
10.1158/1078-0432.CCR-19-3443
Trial ID:
