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Association details:
| Biomarker: | BRAF D549G |
|---|---|
| Cancer: | Melanoma |
| Drug: | U0126 (MEK1 inhibitor, MEK2 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations
Excerpt:
Here we show that the D594G (WM3629) and the G469E (WM3670) melanoma cell lines are nearly completely resistant to the growth inhibitory effects of the MEK inhibitor U0126 (Figure 1B).
DOI:
10.1038/onc.2008.362
