We have identified previously undiscovered BRAF in-frame deletions near the αC-helix region of the kinase domain in pancreatic, lung, ovarian, and thyroid cancers....Expression of L485-P490-deleted BRAF is able to transform NIH/3T3 cells in a BRAF dimer-dependent manner….in the H2405 xenograft model, treatment of LY3009120 at 15 or 30 mg/kg achieved almost complete tumor growth regression, whereas vemurafenib treatment at 20 mg/kg had no antitumor growth activity...Xenograft tumors with a BRAF deletion are sensitive to RAF dimer inhibitor LY3009120 and resistant to the BRAF monomer inhibitor vemurafenib...