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    Association details:
    Biomarker:BNIP3 overexpression
    Cancer:Multiple Myeloma
    Drug:bortezomib (Proteasome inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Hematology
    Title:

    BNIP3 overexpression may promote myeloma cell apoptosis by enhancing sensitivity to bortezomib via the p38 MAPK pathway

    Published date:
    07/04/2023
    Excerpt:
    We investigated the role of BNIP3 overexpression in myeloma cells, and particularly its effects on apoptosis and mitochondria….BNIP3-OE cells exhibited lower viability, and significantly lower viability following BTZ treatment. BTZ-treated BNIP3-OE cells exhibited a significantly higher apoptosis rate than with BTZ-treated vector group...BNIP3 overexpression may promote apoptosis in myeloma cells by enhancing myeloma cell sensitivity to BTZ.
    DOI:
    https://doi.org/10.1080/16078454.2023.2231739