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    Association details:
    Biomarker:BIRC5 mutation
    Cancer:Glioblastoma
    Drug:temozolomide (DNA synthesis inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Cell Mol Life Sci
    Title:

    Localization matters: nuclear-trapped Survivin sensitizes glioblastoma cells to temozolomide by elevating cellular senescence and impairing homologous recombination

    Published date:
    06/08/2021
    Excerpt:
    Orthotopic LN229 xenografts, expressing SurvNES mut exhibited diminished growth and increased DNA damage upon TMZ.
    DOI:
    10.1007/s00018-021-03864-0