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Association details:
| Biomarker: | BIRC2 amplification |
|---|---|
| Cancer: | Melanoma |
| Drug Class: | Immunotherapy |
| Direction: | Resistant |
Evidence:
Source:
Title:
Molecular profiling of Asian patients with advanced melanoma receiving check-point inhibitor treatment
Published date:
12/15/2020
Excerpt:
Next-generation sequencing (NGS) was performed using tumor specimens collected from 178 Asian patients with metastatic melanoma receiving CPIs….Univariate analysis identified TP53 and BRAF mutations, NF2 deletions, and BIRC2 amplifications as poor prognostic factors for PFS (P < 0.05).
DOI:
10.1016/j.esmoop.2020.100002
