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Association details:
Biomarker:BIRC2 amplification
Cancer:Melanoma
Drug Class:Immunotherapy
Direction:Resistant
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
Source:
Title:

Molecular profiling of Asian patients with advanced melanoma receiving check-point inhibitor treatment

Published date:
12/15/2020
Excerpt:
Next-generation sequencing (NGS) was performed using tumor specimens collected from 178 Asian patients with metastatic melanoma receiving CPIs….Univariate analysis identified TP53 and BRAF mutations, NF2 deletions, and BIRC2 amplifications as poor prognostic factors for PFS (P < 0.05).
DOI:
10.1016/j.esmoop.2020.100002