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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Title:

Axitinib and sorafenib are potent in tyrosine kinase inhibitor resistant chronic myeloid leukemia cells

Excerpt:
Using different CML cell lines and models, we identified the clinically approved TKIs sorafenib (SF) and axitinib (AX) as drugs overcoming the resistance mediated by the Bcr Abl(T315I) mutant as well as the one mediated by Gab2 and Lyn(Y508F).
DOI:
10.1186/s12964-016-0129-y