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Association details:
Biomarker:
BCR-ABL1 P465S
Cancer:
Chronic Myeloid Leukemia
Drug:
Scemblix (asciminib)
(
Bcr-abl tyrosine kinase inhibitor
,
STAMP inhibitor
)
Direction:
Resistant
Evidence:
Evidence Level:
Resistant: A2 - Guideline
Source:
NCCN
Published date:
08/05/2022
Excerpt:
Chronic Myeloid Leukemia…The table below lists the BCR::ABL1 kinase domain mutations that should NOT be treated with asciminib…A337T or P465S
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