INDUCTION REGIMENS FOR Ph-POSITIVE ALL: Other Recommended regimens…TKI + vincristine + dexamethasone…TKI options include (in alphabetical order): bosutinib, dasatinib, imanitib, nilotinib or ponatinib.

Tasigna is indicated for the treatment of:...adult and paediatric patients with newly diagnosed Philadelphia chromosome positive chronic myelogenous leukaemia (CML) in the chronic phase…

Our study evaluated the use of nilotinib in combination with chemotherapy in pediatrics with Ph-positive acute leukaemia. These promising results suggest nilotinib based therapy was safe and resulted in deep molecula rresponses in pediatric Ph-positive acute leukaemia with BCR-ABL1-positive and dasatinib intolerance...

Nilotinib combined with low-intensity chemotherapy is well tolerated and highly effective in elderly pts. with Ph-positive ALL.

...72/79 enrolled pts. were evaluable for response, 3 withdrew consent, 4 did not meet eligibility criteria...Sixty-eight of 72 pts. (94.4%) achieved CR, one died during induction and one was refractory, 2 pts discontinued study therapy...EFS and OS at 4 years was 42%, and 47%, respectively...The proportion of pts. with a BCR-ABL1/ABL1 ratio ≤0.1% increased from 41% after induction to 86% after consolidation 2; that of pts. with undetectable or non quantifiable BCR-ABL1 transcripts (sensitivity ≥10-4) increased from 14% to 58%....Nilotinib combined with low intensity chemotherapy is well tolerated and highly effective in elderly pts. with Ph-positive ALL. OS and EFS compare favorably with previous similar studies testing imatinib or dasatinib.