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Association details:
| Biomarker: | BCR-ABL1 F317L |
|---|---|
| Cancer: | Acute Lymphocytic Leukemia |
| Drug: | bosutinib (Bcr-abl tyrosine kinase inhibitor, Src kinase inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Excerpt:
Regimens for relapsed or refractory Ph-positive ALL…Bosutinib has minimal activity against F317L mutation. Nilotinib may be preferred over bosutinib in patients with F317L mutation