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Association details:
| Biomarker: | BCOR mutation |
|---|---|
| Cancer: | Gastrointestinal Cancer |
| Drug Class: | Immunotherapy |
| Direction: | Sensitive |
Evidence:
Source:
Title:
208P - Identification of BCOR mutation as a novel predictor of immunotherapy efficacy in gastrointestinal tumors
Published date:
10/16/2023
Excerpt:
...a multivariable analysis using Cox proportional-hazards regression demonstrated that BCOR-Mut was associated with better OS (HR = 0.29; 95% CI: 0.092-0.93; P = 0.036), after adjusting for age, gender, metastasis and treatment….Survival analysis of MSKCC shows BCOR mutation is an independent predictor of ICIs treatment in GC, rather than a prognostic factor, and may be associated with better immune cell infiltration.
