^
Association details:
Biomarker:BCL3 overexpression
Cancer:Glioma
Drug:temozolomide (DNA synthesis inhibitor)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
New
Source:
Title:

BCL3 expression promotes resistance to alkylating chemotherapy in gliomas

Excerpt:
...whereas overexpression of BCL-3 reduced the efficacy of TMZ (Fig. 1C and fig. S1F). These findings indicate that BCL-3 modulates cytotoxicity induced by TMZ...patients with high BCL3 expression had reduced survival compared to patients with low BCL3 expression...
DOI:
10.1126/scitranslmed.aar2238