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Association details:
| Biomarker: | BBOX1 underexpression |
|---|---|
| Cancer: | Renal Cell Carcinoma |
| Drug: | linifanib (ABT-869) (c-KIT inhibitor, VEGFR inhibitor, PDGFR inhibitor, FLT3 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Low gamma-butyrobetaine dioxygenase (BBOX1) expression as a prognostic biomarker in patients with clear cell renal cell carcinoma: a machine learning approach
Published date:
03/02/2023
Excerpt:
In vitro drug screening showed that midostaurin, BAY-61-3606, GSK690693, and linifanib inhibited the growth of RCC cells with low BBOX1 expression.
DOI:
10.1002/cjp2.315
