^
Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

SINGLE CELL PROFILING OF BCL-2 FAMILY MEMBERS AND CLEAVED CASPASE-3 IN SEARCH OF BIOMARKERS FOR VENETOCLAX TREATMENT IN ACUTE MYELOID LEUKEMIA

Published date:
05/14/2020
Excerpt:
We found a distinct upregulation of BAX in MOLM13 cells treated with 100nM of venetoclax for 7 hours. This effect was even more pronounced after 24 hours of treatment....Furthermore, we demonstrate that the expression of BAX correlates to the expression of cleaved caspase-3, indicating that apoptosis induced by venetoclax is caused by induction of BAX....We hypothesize that the induction of BAX after venetoclax treatment could be a potential biomarker of treatment response.