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Association details:
| Biomarker: | B4GALNT1 expression |
|---|---|
| Cancer: | Retinoblastoma |
| Drug Class: | CAR-T immunotherapy |
| Direction: | Sensitive |
Evidence:
Source:
Title:
GD2-specific chimeric antigen receptor-modified T cells targeting retinoblastoma – assessing tumor and T cell interaction
Published date:
12/10/2020
Excerpt:
Native expression of GD2 on RB cells was demonstrated in human RB cell line - Y79RB….Y79RB-Wasabi cells co-cultured with 4SCAR-GD2 T cells demonstrated a significantly higher rate of tumor cell death...Close to 80% of tumor cells were killed by 24 h after co-culture...with the entire cell population had died by 3 days after co-culture...Thus, 4SCAR-GD2 T cells could effectively target and kill RB tumor cells with high specificity.
DOI:
https://doi.org/10.1016/j.tranon.2020.100971
