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Association details:
| Biomarker: | AXL expression |
|---|---|
| Cancer: | Pancreatic Cancer |
| Drug: | mecbotamab vedotin (BA3011) (Microtubule inhibitor, AXL-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Abstract 827: Anti-tumor efficacy of BA3011, a novel Conditionally Active Biologic (CAB) anti-AXL-ADC
Excerpt:
BA3011 demonstrated the ability to induce cytotoxicity of human tumor cell lines expressing AXL in vitro and inhibit tumor growth in LCLC-103H (lung), DU145 (prostate), and MIAPaCa-2 (pancreatic) human tumor xenografts and in selected gemcitabine resistant pancreatic cancer patient derived xenograft models in vivo.
DOI:
10.1158/1538-7445.AM2018-827
