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Association details:
| Biomarker: | AXL expression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | mipasetamab uzoptirine (ADCT-601) (DNA replication inhibitor, AXL-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody–drug Conjugate Targeting AXL-expressing Cancers
Published date:
04/01/2022
Excerpt:
MDA-MB-231 and PAXF1657 xenografts were developed in female athymic nude mice by implanting 5 × 106 MDA-MB-231 cells...In vivo, ADCT-601 had potent and durable antitumor activity in a wide variety of human cancer xenograft mouse models, including patient-derived xenograft models with heterogeneous AXL expression where ADCT-601 antitumor activity was markedly superior to an auristatin-based comparator ADC.
DOI:
https://doi.org/10.1158/1535-7163.MCT-21-0715
