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    Association details:
    Biomarker:AXL expression
    Cancer:Breast Cancer
    Drug:mipasetamab uzoptirine (ADCT-601) (DNA replication inhibitor, AXL-targeted antibody-drug conjugate)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    New
    Source:
    Mol Cancer Ther
    Title:

    Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody–drug Conjugate Targeting AXL-expressing Cancers

    Published date:
    04/01/2022
    Excerpt:
    MDA-MB-231 and PAXF1657 xenografts were developed in female athymic nude mice by implanting 5 × 106 MDA-MB-231 cells...In vivo, ADCT-601 had potent and durable antitumor activity in a wide variety of human cancer xenograft mouse models, including patient-derived xenograft models with heterogeneous AXL expression where ADCT-601 antitumor activity was markedly superior to an auristatin-based comparator ADC.
    DOI:
    https://doi.org/10.1158/1535-7163.MCT-21-0715