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    Association details:
    Biomarker:AXIN1 deletion
    Cancer:Melanoma
    Drug:PLX4720 (BRAF inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Sci Signal
    Title:

    Wnt/ß-Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAFV600E in Human Melanoma

    Excerpt:
    To determine whether decreased AXIN1 abundance sensitized melanoma cells to PLX4720-mediated apoptosis…These data suggest that loss of AXIN1 preceded caspase-mediated apoptosis
    DOI:
    10.1126/scisignal.2002274