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Association details:
| Biomarker: | AURKA overexpression |
|---|---|
| Cancer: | Adrenal Cortex Carcinoma |
| Drug: | Lysodren (mitotane) (Steroid receptor inhibitor) + AMG 900 (Aurora kinase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The aurora kinase inhibitor AMG 900 increases apoptosis and induces chemosensitivity to anticancer drugs in the NCI-H295 adrenocortical carcinoma cell line
Excerpt:
...AMG 900 inhibited cell proliferation in NCI-H295 cells...it potentialized the mitotane, doxorubicin...effects on apoptosis induction and acted synergistically with mitotane and doxorubicin in the inhibition of proliferation...aurora kinases inhibition using AMG 900 may be an adjuvant therapy to treat patients with invasive or recurrent adrenocortical carcinomas.
DOI:
10.1097/CAD.0000000000000504; 10.1002/pbc.24653
