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Association details:
| Biomarker: | AURKA overexpression |
|---|---|
| Cancer: | Adrenal Cortex Carcinoma |
| Drug: | AMG 900 (Aurora kinase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The aurora kinase inhibitor AMG 900 increases apoptosis and induces chemosensitivity to anticancer drugs in the NCI-H295 adrenocortical carcinoma cell line
Excerpt:
...elevated expression of aurora-A and aurora-B is associated with poor outcome in childhood ACT. Similar results were also reported for adult ACTs...AMG 900 inhibits aurora kinases in adrenocortical carcinoma cells. AMG 900 inhibited cell proliferation in NCI-H295 cells as well as in the ACT primary cultures and caused apoptosis in the cell line NCI-H295...aurora kinases inhibition using AMG 900 may be an adjuvant therapy to treat patients with invasive or recurrent adrenocortical carcinomas.
DOI:
10.1097/CAD.0000000000000504; 10.1002/pbc.24653
