^
Association details:
| Biomarker: | ATXN1L deletion |
|---|---|
| Cancer: | Pancreatic Cancer |
| Drug: | Mekinist (trametinib) (MEK inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition
Excerpt:
These observations suggest that loss of ATXN1L mediates resistance to MEK inhibition by reducing CIC levels, which permits increased expression of ETV1, 4, and 5.
DOI:
10.1016/j.celrep.2017.01.031
