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    Association details:
    Biomarker:ATP6AP2 overexpression
    Cancer:Acute Myelogenous Leukemia
    Drug:etoposide IV (Topoisomerase II inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    Source:
    PLoS One
    Title:

    Renin angiotensin system genes are biomarkers for personalized treatment of acute myeloid leukemia with Doxorubicin as well as etoposide

    Published date:
    11/25/2020
    Excerpt:
    We show that the combined in silico analysis of up to five RAS genes can reliably predict sensitivity to Doxorubicin as well as Etoposide in AML... Patients classifed in high expression group of IGF2R and CTSA showed better overall survival when compared with low expression group and high expression group of ATP6AP2 showed worse survival when compared with low expression group.
    DOI:
    10.1371/journal.pone.0242497