We show that the combined in silico analysis of up to five RAS genes can reliably predict sensitivity to Doxorubicin as well as Etoposide in AML... Patients classifed in high expression group of IGF2R and CTSA showed better overall survival when compared with low expression group and high expression group of ATP6AP2 showed worse survival when compared with low expression group....ATP6AP2 was associated to resistance and IGF2R and CTSA were associated to sensitivity for Doxorubicin in silico and in vitro.