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Association details:
| Biomarker: | ATM deletion |
|---|---|
| Cancer: | Mantle Cell Lymphoma |
| Drug: | ART558 (DNA polymerase theta inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
6208 / 10 - Targeting DNA polymerase theta and ATM leads to synergistic killing of mantle cell lymphoma cells
Published date:
03/15/2023
Excerpt:
In vitro, single-agent treatment with novobiocin or ART558 caused a significant cytotoxic effect at physiologically relevant concentrations in ATM-deficient cells…Our data has the potential to uncover novel biomarker-driven drug therapy of POLQ inhibitors in R/R MCL.
