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Association details:
| Biomarker: | ATIC deletion |
|---|---|
| Cancer: | Hepatocellular Cancer |
| Drug Class: | AMPK inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling
Excerpt:
Our previous data indicated that AMPK was markedly activated in ATIC-deficient cells. To determine whether AMPK is involved in ATIC induced migration of HCC cells, the above mentioned ATIC shRNA 1 or shScr was transfected into HepG2 cells followed by treating with or without AMPK inhibitor C-C. Wound-healing assay results showed that C-C treatment rescued ATIC-deficient induced migration inhibition...In addition, 10 μM C-C treatment caused tumor cell growth similar to level of shScr transfected HepG2 cells further supporting that AMPK inhibition rescued ATIC deficiency...
DOI:
10.1186/s12964-017-0208-8
