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Association details:
| Biomarker: | ATG5 overexpression |
|---|---|
| Cancer: | Gastric Cancer |
| Regimen: | ECF (5-fluorouracil + cisplatin + epirubicin) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Upregulation of Autophagy-Related Gene-5 (ATG-5) Is Associated with Chemoresistance in Human Gastric Cancer
Excerpt:
135 gastric cancers (GC) patients who were treated with epirubicin, cisplatin and 5-FU adjuvant chemotherapy (ECF) following surgical resection and explored their potential clinical significance...The Kaplan-Meier survival analysis revealed a higher ATG-5 expression was significantly associated with poorer OS (P<0.001) and DFS (P = 0.003).
DOI:
https://doi.org/10.1371/journal.pone.0110293
